Hasan Mukhtar Selected Research

lupeol

11/2013	The dietary terpene lupeol targets colorectal cancer cells with constitutively active Wnt/β-catenin signaling.
10/2010	Specific targeting of Wnt/β-catenin signaling in human melanoma cells by a dietary triterpene lupeol.
5/2009	Lupeol inhibits proliferation of human prostate cancer cells by targeting beta-catenin signaling.
2/2009	Suppression of cFLIP by lupeol, a dietary triterpene, is sufficient to overcome resistance to TRAIL-mediated apoptosis in chemoresistant human pancreatic cancer cells.
4/2008	Lupeol inhibits growth of highly aggressive human metastatic melanoma cells in vitro and in vivo by inducing apoptosis.
3/2008	Cancer chemoprevention through dietary antioxidants: progress and promise.
12/2005	A novel dietary triterpene Lupeol induces fas-mediated apoptotic death of androgen-sensitive prostate cancer cells and inhibits tumor growth in a xenograft model.
11/2005	Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway.
7/2004	Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice.

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Hasan Mukhtar Research Topics

Disease

142	Neoplasms (Cancer) 01/2022 - 01/2002
76	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 02/2002
27	Carcinogenesis 12/2019 - 01/2002
18	Skin Neoplasms (Skin Cancer) 01/2015 - 01/2002
15	Carcinoma (Carcinomatosis) 01/2019 - 05/2002
15	Melanoma (Melanoma, Malignant) 10/2018 - 04/2005
11	Inflammation (Inflammations) 01/2019 - 02/2003
11	Neoplasm Metastasis (Metastasis) 01/2018 - 01/2003
11	Adenocarcinoma 03/2011 - 01/2003
9	Hyperplasia 01/2019 - 01/2003
7	Edema (Dropsy) 11/2010 - 11/2003
6	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2019 - 03/2008
5	Colonic Neoplasms (Colon Cancer) 12/2019 - 06/2005
5	Colorectal Neoplasms (Colorectal Cancer) 12/2019 - 10/2007
5	Skin Diseases (Skin Disease) 01/2019 - 11/2003
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 07/2007
4	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2015 - 08/2003
3	Cardiotoxicity 01/2020 - 01/2020
3	Leukemia 01/2019 - 10/2007
3	Disease Progression 10/2018 - 02/2006
3	Dermatitis 01/2018 - 03/2008
3	Lung Neoplasms (Lung Cancer) 01/2017 - 04/2012
3	Pancreatic Neoplasms (Pancreatic Cancer) 11/2009 - 11/2005
2	Obesity 12/2019 - 04/2015
2	Atherosclerosis 01/2018 - 01/2013
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2017 - 04/2012

Drug/Important Bio-Agent (IBA)

49	TeaIBA 12/2018 - 02/2002
34	PolyphenolsIBA 01/2020 - 02/2002
29	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2003
22	AntioxidantsIBA 01/2022 - 04/2002
21	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 01/2020 - 02/2002
21	fisetinIBA 12/2019 - 05/2008
16	FlavonoidsIBA 12/2019 - 05/2002
15	AndrogensIBA 01/2021 - 05/2002
15	NF-kappa B (NF-kB)IBA 01/2014 - 05/2002
13	Biomarkers (Surrogate Marker)IBA 01/2021 - 03/2004
11	Prostate-Specific Antigen (Semenogelase)IBA 01/2021 - 10/2005
10	TriterpenesIBA 10/2018 - 11/2005
9	Phosphotransferases (Kinase)IBA 01/2019 - 08/2004
9	Therapeutic UsesIBA 01/2016 - 04/2004
9	lupeolIBA 11/2013 - 07/2004
9	Guanosine Triphosphate (GTP)IBA 03/2013 - 01/2003
8	delphinidinIBA 10/2017 - 08/2008
8	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2015 - 04/2005
7	Pharmaceutical PreparationsIBA 01/2022 - 08/2003
7	ResveratrolIBA 01/2020 - 03/2008
7	PhytochemicalsIBA 01/2019 - 01/2008
7	Biological ProductsIBA 05/2017 - 01/2007
7	Messenger RNA (mRNA)IBA 01/2017 - 01/2003
7	Anthocyanins (Anthocyanin)IBA 01/2015 - 01/2005
6	CyclinsIBA 01/2016 - 02/2003
6	Insulin-Like Growth Factor I (IGF-1)IBA 03/2012 - 12/2004
6	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 11/2010 - 07/2002
6	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 02/2009 - 07/2002
5	CytokinesIBA 01/2019 - 07/2009
5	Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA 11/2010 - 03/2004
4	Androgen Receptors (Androgen Receptor)IBA 01/2021 - 10/2008
4	EnzymesIBA 01/2020 - 07/2002
4	CateninsIBA 11/2013 - 10/2010
4	Sunscreening Agents (Sunscreens)IBA 03/2008 - 04/2002
4	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2006 - 04/2002
4	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 04/2005 - 03/2003
3	LipidsIBA 01/2020 - 11/2003
3	Ethanol (Ethyl Alcohol)IBA 01/2020 - 07/2007
3	CurcuminIBA 01/2020 - 10/2007
3	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2020 - 07/2013
3	Glucose (Dextrose)FDA LinkGeneric 12/2019 - 04/2015
3	Matrix Metalloproteinases (MMPs)IBA 10/2018 - 01/2003
3	LigandsIBA 01/2018 - 02/2009
3	ChitosanIBA 01/2018 - 02/2014
3	Imiquimod (Aldara)FDA LinkGeneric 01/2018 - 01/2016
3	AntigensIBA 01/2017 - 03/2013
3	SeleniumIBA 06/2014 - 11/2008
3	Vitamin E FDA LinkGeneric 06/2014 - 11/2008
3	Calcium-Binding ProteinsIBA 05/2013 - 01/2003
3	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 04/2012 - 02/2004
3	Cyclin D1IBA 10/2010 - 04/2005
3	Drinking WaterIBA 03/2009 - 03/2007
3	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2008 - 03/2005
3	sanguinarineIBA 07/2007 - 08/2003
3	cytoplasmic antiproteinaseIBA 10/2006 - 02/2006
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2006 - 01/2003
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2022 - 03/2003
2	Free RadicalsIBA 01/2020 - 01/2020
2	dikanutIBA 01/2020 - 01/2020
2	CatalaseIBA 01/2020 - 03/2012
2	QuercetinIBA 01/2020 - 01/2016
2	AcidsIBA 10/2018 - 04/2015
2	ChemokinesIBA 01/2018 - 10/2017
2	plectranthoic acidIBA 01/2018 - 01/2016
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 04/2015 - 09/2004
2	Transcription Factors (Transcription Factor)IBA 01/2015 - 03/2004
2	AMP-Activated Protein KinasesIBA 12/2014 - 09/2008

Therapy/Procedure

49	Chemoprevention 10/2017 - 01/2002
36	Therapeutics 01/2022 - 05/2002
9	Drug Therapy (Chemotherapy) 12/2016 - 10/2005
8	Oral Administration 02/2014 - 10/2005
3	Intraperitoneal Injections 01/2021 - 01/2015
3	Radiotherapy 04/2015 - 01/2003
2	Diet Therapy (Therapy, Diet) 04/2015 - 03/2008